Anti-KDM5C / Jarid1C / SMCX Antibody [PCRP-KDM5C-1A11] (A315210)

Anti-KDM5C / Jarid1C / SMCX Antibody [PCRP-KDM5C-1A11]

Mouse monoclonal [PCRP-KDM5C-1A11] antibody to KDM5C / Jarid1C / SMCX.

SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

HeLa cells.

Flow Cytometry: 1-2 µg/million cells

Human

Recombinant full-length human KDM5C protein.

Mouse

Monoclonal

IgG2c

Protein A/G chromatography.

200 µg/ml

176 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DXS1272E, Histone demethylase JARID1C, JARID1C, JmjC domain containing protein SMCX, Jumonji AT rich interactive domain 1C, Jumonji, AT rich interactive domain 1C (RBP2 like), Jumonji/ARID domain-containing protein 1C, KDM5C, KDM5C_HUMAN, Lysine (K) specific demethylase 5C, Lysine-specific demethylase 5C, MRX13, MRXJ, MRXSCJ, MRXSJ, Protein SmcX, Protein Xe169, rbp2 like protein, Selected cDNA on X, SMCX, Smcx homolog X chromosome, SmcX protein, Smcy homolog X linked, XE169, Xe169 protein