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Anti-KIF14 Antibody

Rabbit polyclonal antibody to KIF14 from ABclonal (A10275).
Name: Anti-KIF14 Antibody
Description: Rabbit polyclonal antibody to KIF14.
Applications: WB
Dilutions: WB: 1:1000 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human KIF14.
Protein Length: 1648
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).
Involvement in Disease: Meckel syndrome 12: A form of Meckel syndrome, a disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.
Sequence Similarities: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Cellular Location: Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Spindle. Midbody.

Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring.
UniProt: Q15058
Gene ID: 9928
Synonyms: KIAA0042 Antibody
KIF 14 Antibody
KIF14_HUMAN Antibody
Kinesin Family Member 14 Antibody
Kinesin like protein KIF14 Antibody
Kinesin-like protein KIF14 Antibody
MGC142302 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extract of various cells, using KIF14 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to KIF14
Application: ELISA, IHC, IP, WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 850-960 on human KIF14 protein.

£372

Description: Rabbit polyclonal antibody to KIF14
Application: IHC
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide of human KIF14

£234

Application: WB
Immunogen: Purified Protein
UniProt: Q15058
Accession No: NP_055690

£234





Please Note: Anti-KIF14 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10275
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe