|Description:||Rabbit polyclonal antibody to KIF16B.|
|Dilutions:||WB: 1:200 - 1:2000.|
|Immunogen:||Recombinant protein of human KIF16B.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.|
|Tissue Specificity:||Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).|
|Sequence Similarities:||Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|
|Cellular Location:||Cytoplasm > Cytoskeleton. Early endosome membrane.
It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.
|Synonyms:||Chromosome 20 open reading frame 23 Antibody
Kinesin like motor protein C20orf23 Antibody
Sorting nexin 23 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|