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Anti-KLF1 Antibody

Rabbit polyclonal antibody to KLF1 from ABclonal (A10581).
Name: Anti-KLF1 Antibody
Description: Rabbit polyclonal antibody to KLF1.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human
Immunogen: A synthetic peptide of human KLF1.
Protein Length: 362
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Tissue Specificity: Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
Involvement in Disease: Anemia, congenital dyserythropoietic, 4: A blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin.
Sequence Similarities: Belongs to the krueppel C2H2-type zinc-finger protein family.
Post-Translational Modification: Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity (By similarity).
Cellular Location: Nucleus.

Colocalizes with SUMO1 in nuclear speckles.
UniProt: Q13351
Gene ID: 10661
Synonyms: CDAN4 Antibody
EKLF Antibody
EKLF / KLF1 Antibody
EKLF PEN Antibody
Erythroid krueppel like transcription factor (EKLF) (Erythroid transcription factor) Antibody
Erythroid krueppel-like transcription factor Antibody
Erythroid Kruppel like factor Antibody
Erythroid specific transcription factor EKLF Antibody
HBFQTL6 Antibody
Human erythroid-specific transcription factor EKLF mRNA complete cds Antibody
INLU Antibody
KLF1_HUMAN Antibody
Krueppel-like factor 1 Antibody
Kruppel like factor 1 (erythroid) Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cell lines, using KLF1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (1)
Description: Rabbit polyclonal antibody to EKLF (W318)
Application: WB, IF
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 288-335 of Human EKLF.

£165 – £283

Description: Rabbit polyclonal antibody to EKLF / CKLF / UKLF
Application: WB, IF, ELISA
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the C-terminal region of human EKLF / CKLF / UKLF.

£180 – £234

Description: Goat polyclonal antibody to KLF1.
Application: ELISA, IHC, ChIP
Host: Goat
Isotype: IgG
Reactivity: Human, Mouse

£205

Description: Rabbit polyclonal antibody to EKLF
Application: WB, ELISA
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized peptide derived from human EKLF around the non-acetylation site of K274.

£180 – £234

Please Note: Anti-KLF1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10581
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £20 to United Kingdom
  • £35 to Europe