Anti-LOX 1 Antibody [DE17-4B9] (Biotin) (A280236)

$420

Mouse monoclonal [DE17-4B9] antibody to LOX 1 (Biotin) for ELISA.

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-LOX 1 Antibody [DE17-4B9] (Biotin)
Description
Mouse monoclonal [DE17-4B9] antibody to LOX 1 (Biotin).
Specificity
This antibody recognises lectin-like oxidized LDL receptor 1 (LOX-1) also known as oxidized low density lipoprotein receptor 1 and C-type lectin domain family 8 member A. LOX-1 is a 5 kDa transmembrane glycoprotein and is a member of the class E of the scavenger receptors. It is expressed in a variety of cells including macrophages, vascular smooth muscle cells, cardiomyocytes, platelets and fibroblasts. Proteolytic cleavage of LOX-1 results in the soluble form sLOX-1. The ligand Ox-LDL exerts its biological effects through the LOX-1 receptor, with its binding resulting in induction of the MAPK or NF-?B signaling pathways. Downstream of this, these pathways can trigger the induction of the productions of adhesion molecules and pro-inflammatory cytokines (https://pubmed.ncbi.nlm.nih.gov/30819724/).LOX-1 is expressed at low levels under normal physiological conditions, but is upregulated in various pathological conditions including atherosclerosis, diabetes mellitus, hypertension and dyslipidemia. The biotinylated Mouse anti Human LOX-1 antibody, clone DE17-4B9 (MCA6251B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human LOX-1 antibody, clone DE15-4H4 (MCA6250GA) as the capture antibody.
Applications
ELISA
Dilutions
ELISA: 1 µg/ml
Reactivity
Human
Immunogen
HEK293 derived recombinant human full length LOX-1 (Ser61-Gln273).
Host
Mouse
Clonality
Monoclonal
Clone ID
DE17-4B9
Isotype
IgG2b
Conjugate

Biotin

Purification
Protein G affinity chromatography of tissue culture supernatant.
Concentration
100 µg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.
General Notes
Mouse anti Human LOX-1 antibody, clone DE17-4B9, recognizes lectin-like oxidized LDL receptor 1 (LOX-1) also known as oxidized low density lipoprotein receptor 1 and C-type lectin domain family 8 member A. LOX-1 is a 5 kDa transmembrane glycoprotein and is a member of the class E of the scavenger receptors. It is expressed in a variety of cells including macrophages, vascular smooth muscle cells, cardiomyocytes, platelets and fibroblasts (Kattoor et al. 2019). Proteolytic cleavage of LOX-1 results in the soluble form sLOX-1. The ligand Ox-LDL exerts its biological effects through the LOX-1 receptor, with its binding resulting in induction of the MAPK or NF-?B signaling pathways. Downstream of this, these pathways can trigger the induction of the productions of adhesion molecules and pro-inflammatory cytokines (https://pubmed.ncbi.nlm.nih.gov/30819724/). LOX-1 is expressed at low levels under normal physiological conditions, but is upregulated in various pathological conditions including atherosclerosis, diabetes mellitus, hypertension and dyslipidemia (Kattoor et al. 2019). The biotinylated Mouse anti Human LOX-1 antibody, clone DE17-4B9 (MCA6251B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human LOX-1 antibody, clone DE15-4H4 (MCA6250GA) as the capture antibody.
Synonyms
C-type lectin domain family 8 member A, CLEC8A, hLOX 1, hLOX-1, Lectin like oxidized LDL receptor 1, Lectin like oxLDL receptor 1, Lectin type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, low density lipoprotein oxidized, receptor 1, LOX-1, LOXIN, Olr1, OLR1_HUMAN, Ox LDL receptor 1, Ox-LDL receptor 1, Oxidised low density lipoprotein (lectin like) receptor 1, Oxidized low density lipoprotein (lectin like) receptor 1, Oxidized low density lipoprotein receptor 1, Oxidized low density lipoprotein receptor 1 soluble form, Oxidized low-density lipoprotein receptor 1, SCARE1, Scavenger receptor class E member 1, Scavenger receptor class E, member 1, SLOX1, soluble form, SR-EI
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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