Anti-Luteinizing Hormone alpha Antibody [LHa/756] (A248166)

Anti-Luteinizing Hormone alpha Antibody [LHa/756]

Mouse monoclonal [LHa/756] antibody to Luteinizing Hormone alpha.

This antibody reacts with a protein of ~13kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human LH alpha protein.

Mouse

Monoclonal

LHa/756

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

~13 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Luteinizing Hormone alpha Antibody [LHa/756] - BSA and Azide free (A251349).

Anterior pituitary glycoprotein hormones common subunit alpha, CG alpha, CG-alpha, cga, Choriogonadotropin alpha chain, Chorionic Gonadotrophin Alpha, Chorionic Gonadotrophin Alpha Subunit, Chorionic gonadotrophin subunit alpha, chorionic gonadotropin, alpha polypeptide, Follicle-stimulating hormone alpha, Follicle-stimulating hormone alpha chain, follicle-stimulating hormone alpha subunit, Follitropin alpha, Follitropin alpha chain, FSH Alpha, FSH-alpha, FSHA, GLHA_HUMAN, Glycoprotein hormones alpha chain, Glycoprotein Hormones Alpha Polypeptide, GPH Alpha, GPHa, GPHA1, HCG, hCG alpha, hyrotropin alpha, LH-alpha, LHA, LSH alpha, LSH-alpha, Luteinizing hormone alpha chain, Lutropin alpha, Lutropin alpha chain, Thyroid Stimulating Hormone Alpha, Thyroid Stimulating Hormone Alpha Chain, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, TSH Alpha, TSH-alpha, TSHA