Anti-MCP1 Antibody [AA07-3B8] (A279616)

Anti-MCP1 Antibody [AA07-3B8]

Mouse monoclonal [AA07-3B8] antibody to MCP1.

This antibody recognises C-C motif chemokine 2, also known as MCP1, HC11, and MCAF. CCL2 is a constitutively expressed chemokine, which is upregulated during the inflammatory response and promotes recruitment of immune cells to specific sites. Many cell types can produce CCL2, including endothelial, epithelial, myeloid, smooth muscle cells and fibroblasts, and CCL2 is able to recruit monocytes, basophils, T lymphocytes and NK cells. CCL2 promotes cancer development and metastasis through binding to the cognate receptor CCR2, and CCL2-CCR2 signaling has multiple tumorigenic roles. The tumor microenvironment itself produces CCL2, which facilitates the accumulation of tumor associated macrophages (TAMs), which have immune suppressive and tumor promoting functions. The purified Mouse anti Human CCL2 antibody, clone AA07-3B8 (MCA6218GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL2 antibody, clone AA03-4H10 (MCA6219B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human CCL2 (Gln24-Thr99).

Mouse

Monoclonal

AA07-3B8

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CCL2 antibody, clone AA07-3B8, recognizes C-C motif chemokine 2, also known as MCP1, HC11, and MCAF. CCL2 is a constitutively expressed chemokine, which is upregulated during the inflammatory response and promotes recruitment of immune cells to specific sites. Many cell types can produce CCL2, including endothelial, epithelial, myeloid, smooth muscle cells and fibroblasts, and CCL2 is able to recruit monocytes, basophils, T lymphocytes and NK cells (Lim et al. 2016). CCL2 promotes cancer development and metastasis through binding to the cognate receptor CCR2, and CCL2-CCR2 signaling has multiple tumorigenic roles. The tumor microenvironment itself produces CCL2, which facilitates the accumulation of tumor associated macrophages (TAMs), which have immune suppressive and tumor promoting functions (Yoshimura et al. 2018). The purified Mouse anti Human CCL2 antibody, clone AA07-3B8 (MCA6218GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL2 antibody, clone AA03-4H10 (MCA6219B) as the detection antibody.

C-C motif chemokine 2, CCL2, CCL2_HUMAN, Chemokine (C C motif) ligand 2, GDCF 2, GDCF-2, GDCF2, HC11, HSMCR30, JE, MCAF, MCP 1, MCP-1, MGC9434, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, Monocyte chemotactic protein 1, Monocyte secretory protein JE, SCYA2, Small inducible cytokine A2, Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je), Small inducible cytokine subfamily A (Cys Cys), member 2, Small-inducible cytokine A2, SMC CF, SMC-CF, SMCCF