Anti-MED7 Antibody [PCRP-MED7-1B8] (A277851)

Mouse monoclonal [PCRP-MED7-1B8] antibody to MED7 for ELISA, Flow Cytometry, IF and IP.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-MED7 Antibody [PCRP-MED7-1B8]
Description
Mouse monoclonal [PCRP-MED7-1B8] antibody to MED7.
Specificity
MED7, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.
Applications
ELISA, Flow Cytometry, IF, IP
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IP: 1-2µg / 100-500µg proteins
Reactivity
Human
Immunogen
Recombinant full-length human MED7 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-MED7-1B8
Isotype
IgG2b
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
27.2 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MED7 Antibody [PCRP-MED7-1B8] - BSA and Azide free (A278439).
Synonyms
Activator recruited cofactor 34 kDa component, Activator-recruited cofactor 34 kDa component, ARC34, Cofactor required for Sp1 transcriptional activation subunit 9, Cofactor required for Sp1 transcriptional activation, subunit 9 (33kD), Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, CRSP complex subunit 9, CRSP33, CRSP9, hMED7, MED7_HUMAN, Mediator complex subunit 7, Mediator of RNA polymerase II transcription subunit 7, MGC12284, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
Publishing research using Anti-MED7 Antibody [PCRP-MED7-1B8] (A277851)? Please let us know so that we can list the citation on this page.

Alternative products to Anti-MED7 Antibody [PCRP-MED7-1B8] (A277851)

Top