Anti-MEF2B Antibody [PCRP-MEF2B-2F9] (A277524)

Anti-MEF2B Antibody [PCRP-MEF2B-2F9]

Mouse monoclonal [PCRP-MEF2B-2F9] antibody to MEF2B.

The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.

IP, WB, Flow Cytometry, IF

IP: 1-2µg / 100-500µg proteins, WB: 1-2 µg/ml, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Recombinant full-length human MEF2B protein.

Mouse

Monoclonal

PCRP-MEF2B-2F9

IgG2a

Protein A/G chromatography.

200 µg/ml

160 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MEF2B Antibody [PCRP-MEF2B-2F9] - BSA and Azide free (A278112).

MADS box transcription enhancer factor 2, MDS1 EVI1, MEF2B_HUMAN, Myocyte enhancer factor 2B, Myocyte specific enhancer factor 2B, Myocyte-specific enhancer factor 2B, PRDM3, RSRFR2, Serum response factor like protein 2, Serum response factor-like protein 2, XMEF2