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Anti-MLKL Antibody

Rabbit monoclonal antibody to MLKL from ABclonal (A11458).
Name: Anti-MLKL Antibody
Description: Rabbit monoclonal antibody to MLKL.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human
Immunogen: Recombinant protein of human MLKL.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Sequence Similarities: Belongs to the protein kinase superfamily.
Post-Translational Modification: Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Cellular Location: Cytoplasm. Cell membrane.

Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
UniProt: Q8NB16
Gene ID: 197259
Synonyms: 9130019I15Rik Antibody
FLJ34389 Antibody
hMLKL Antibody
Mixed lineage kinase domain like Antibody
Mixed lineage kinase domain like protein Antibody
Mixed lineage kinase domain-like protein Antibody
MLKL_HUMAN Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cells, using MLKL antibody.
Immunohistochemistry of paraffin-embedded human tonsil using MLKL antibody at dilution of 1:100 (40x lens).
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (5)
Description: Rabbit polyclonal antibody to MLKL.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human

£148 – £372

Description: Rabbit monoclonal antibody to MLKL
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant antibody.

£269 – £400

Description: Rabbit polyclonal antibody to MLKL
Application: WB, ELISA
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized peptide derived from the N-terminal region of human MLKL.

£180 – £234

Description: Rabbit polyclonal antibody to MLKL
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human MLKL.

£234

Please Note: Anti-MLKL Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A11458
Size Price Quantity
100µl £372
200µl £565

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe