|Description:||Rabbit monoclonal antibody to MLKL.|
|Dilutions:||WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.|
|Immunogen:||Recombinant protein of human MLKL.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.|
|Sequence Similarities:||Belongs to the protein kinase superfamily.|
|Post-Translational Modification:||Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.|
|Cellular Location:||Cytoplasm. Cell membrane.
Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Mixed lineage kinase domain like Antibody
Mixed lineage kinase domain like protein Antibody
Mixed lineage kinase domain-like protein Antibody
|Information:||Target information shown above is from the UniProt Consortium.|