Anti-n-Myc Antibody [NMYC-1] (A249458)

Anti-n-Myc Antibody [NMYC-1]

Mouse monoclonal [NMYC-1] antibody to n-Myc.

The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

IF, WB

IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human, Mouse, Rat

Recombinant full-length human n-Myc protein.

Mouse

Monoclonal

NMYC-1

IgG2a

kappa

Unconjugated

200 µg/ml

67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-n-Myc Antibody [NMYC-1] - BSA and Azide free (A252638).

bHLHe37, Class E basic helix-loop-helix protein 37, MODED, mycn, MYCN_HUMAN, N myc, N myc proto oncogene protein, N-myc proto-oncogene protein, Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene, Neuroblastoma MYC oncogene, NMYC, NMYC proto oncogene protein, ODED, Oncogene NMYC, pp65/67, V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, v myc avian myelocytomatosis viral related oncogene neuroblastoma derived, v myc myelocytomatosis viral related oncogene neuroblastoma derived