Anti-NCR1 Antibody [VIV-KM1] (A281923)

Anti-NCR1 Antibody [VIV-KM1]

Mouse monoclonal [VIV-KM1] antibody to NCR1.

This antibody recognises the porcine homologue of human CD335, also known as NKp46 and natural cytotoxicity triggering receptor 1 (NCR1), a member of the natural cytotoxicity receptor (NCR) family.CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor and is involved in the control of viral infection and tumor development. CD335 is expressed by human natural killer cells. The development of monoclonal antibodies to bovine CD335 (clone AKS1) and ovine CD335 (clone EC1.1) have enabled researchers to identify and better understand ruminant NK cells. Mouse anti Pig CD335 antibody, clone VIV-KM is the first monoclonal developed to specifically identify porcine CD335 and provides a reagent to facilitate a better understanding of the pig immune system and aid in the understanding of the role of NK cells in host pathogen defense. Porcine CD335 is not expressed by all NK cells and expression may be influenced by cytokine production.

IF, Flow Cytometry

Flow Cytometry: 1:50 - 1:200, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl.

Porcine

Fusion protein consisting of the extracellular region of porcine CD335.

Mouse

Monoclonal

VIV-KM1

IgG1

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Pig CD335 antibody, clone VIV-KM1 recognizes the porcine homologue of human CD335, also known as NKp46 and natural cytotoxicity triggering receptor 1 (NCR1), a member of the natural cytotoxicity receptor (NCR) family.CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor and is involved in the control of viral infection and tumor development. CD335 is expressed by human natural killer cells (Sivori et al.1997). The development of monoclonal antibodies to bovine CD335 (clone AKS1) (Storset et al. 2004) and ovine CD335 (clone EC1.1) (Connelley et al.2011) have enabled researchers to identify and better understand ruminant NK cells.Mouse anti Pig CD335 antibody, clone VIV-KM is the first monoclonal developed to specifically identify porcine CD335 and provides a reagent to facilitate a better understanding of the pig immune system and aid in the understanding of the role of NK cells in host pathogen defense. Porcine CD335 is not expressed by all NK cells and expression may be influenced by cytokine production (Mair et al. 2012).

Activating NK receptor NK p46, CD335, FLJ99094, hNKp46, Ly94, Lymphocyte antigen 94, Lymphocyte antigen 94 homolog, Lymphocyte antigen 94 homolog (activating NK receptor; NK p46), Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCT1, NCTR1_HUMAN, NK cell activating receptor, NK cell-activating receptor, NK-p46, NKp46