Anti-NFkB p105 Antibody (A283359)

Anti-NFkB p105 Antibody

Rabbit polyclonal antibody to NFkB p105.

This antibody recognises Nuclear factor NF-kappa-B p105 subunit also known as DNA-binding factor KBF1 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. NF-kappa-B p105 is a large precursor protein that is cleaved at its C-terminus, containing a number of ankyrin repeats, by the ubiquitin/proteasome pathway into the NF-kappa-B p50 subunit. The p50 subunit is also known as NF-?B1 and interacts with members of the Rel protein family to form transcription factors. In the absence of stimulation an I-kappa-B inhibitory protein mediated sequestration mechanism ensures that the transcription factors remain in the cytoplasm. Upon stimulation, I-kappa-B proteins become phosphorylated, which results in their ubiquitylation and subsequent degradation by the 26S proteasome.The NF-kappa-B pathway plays a critical in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.

WB: 0.5 - 4.0 µg/ml

Human, Mouse, Rat

Synthetic peptide corresponding to residues surrounding amino acid 955 of human NFkB p105.

Rabbit

Polyclonal

IgG

500 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 30% Glycerol, 0.5% BSA, and 0.01% Thiomersal.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti NFkB p105 antibody recognizes Nuclear factor NF-kappa-B p105 subunit also known as DNA-binding factor KBF1 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. NF-kappa-B p105 is a large precursor protein that is cleaved at its C-terminus, containing a number of ankyrin repeats, by the ubiquitin/proteasome pathway into the NF-kappa-B p50 subunit. The p50 subunit is also known as NF-?B1 and interacts with members of the Rel protein family to form transcription factors. In the absence of stimulation an I-kappa-B inhibitory protein mediated sequestration mechanism ensures that the transcription factors remain in the cytoplasm. Upon stimulation, I-kappa-B proteins become phosphorylated, which results in their ubiquitylation and subsequent degradation by the 26S proteasome.The NF-kappa-B pathway plays a critical in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.

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