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Anti-NPC1L1 Antibody

Rabbit polyclonal antibody to NPC1L1 from ABclonal (A10049).
Name: Anti-NPC1L1 Antibody
Description: Rabbit polyclonal antibody to NPC1L1.
Applications: WB
Dilutions: WB: 1:1000 - 1:4000.
Reactivity: Human
Immunogen: Recombinant protein of human NPC1L1.
Protein Length: 1359 (1332)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Tissue Specificity: Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
Sequence Similarities: Belongs to the patched family.
Post-Translational Modification: Highly glycosylated.
Cellular Location: Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane.

Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
UniProt: Q9UHC9
Gene ID: 29881
Synonyms: Niemann Pick C1 Like 1 Antibody
Niemann Pick C1 like protein 1 Antibody
Niemann Pick disease type C1 gene like 1 Antibody
Niemann-Pick C1-like protein 1 Antibody
NPC1 LIKE 1 Antibody
NPC1 Niemann Pick disease type C1 gene like 1 Antibody
NPC1L1 splice variant Antibody
NPCL1_HUMAN Antibody
Truncated Niemann Pick C1 like protein 1 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cells, using NPC1L1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Please Note: Anti-NPC1L1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10049
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe