Anti-Nucleolin Antibody [NCL/7339] (A315411)

$765

Mouse monoclonal [NCL/7339] antibody to Nucleolin for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Nucleolin Antibody [NCL/7339]
Description
Mouse monoclonal [NCL/7339] antibody to Nucleolin.
Specificity
Recognizes a protein of ~76kDa, which is identified as Nucleolin (NCL). It is the major nucleolar phosphoprotein of growing eukaryotic cells. NCL is located mainly in dense fibrillar regions of the nucleolus. It is found associated with intranucleolar chromatin and pre-ribosomal particles. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly.This MAb can be used to stain the nucleoli in cell or tissue preparations and can be used as a marker of the nucleoli in subcellular fractions. It produces a speckled pattern in the nuclei of cells of normal and malignant cells and may be used to stain the nucleoli of cells in fixed or frozen tissue sections. It can be used with paraformaldehyde fixed frozen tissue or cell preparations and formalin fixed, paraffin-embedded tissue sections.
Applications
IHC-P
Positive Control
All human cells. Human testis, ovary or Hodgkin s lymphoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Cross Reactivity
This antibody does not react with Mouse, Cat, Cow, Dog or Horse.
Immunogen
Recombinant full-length human NCL protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
NCL/7339
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
76 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
C23, FLJ45706, MS1116, NCL, Nucl, NUCL_HUMAN, Protein C23
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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