Anti-ORC1 Antibody [7F6/1] (A249550)

Anti-ORC1 Antibody [7F6/1]

Mouse monoclonal [7F6/1] antibody to ORC1.

The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.

Human

Recombinant full-length human ORC1 protein.

Mouse

Monoclonal

7F6/1

IgG1

kappa

Unconjugated

200 µg/ml

120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ORC1 Antibody [7F6/1] - BSA and Azide free (A252730).

HSORC1, MmORC1, ORC1L, ORC1_HUMAN, Origin Recognition Complex 1, Origin recognition complex subunit 1, Origin recognition complex subunit 1 (yeast homolog) like, Origin recognition complex subunit 1 homolog, Origin recognition complex subunit 1 like, Origin recognition complex subunit 1 like (S. cerevisia, Origin recognition complex subunit 1 S. cerevisiae homolog like , Origin recognition complex, subunit 1 like (yeast), PARC1, Replication control protein 1