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Anti-Particulate Guanylate Cyclase C Antibody (FITC)

 
Rabbit polyclonal antibody to Particulate Guanylate Cyclase C (FITC) from FabGennix (PGCC-FITC).
Overview
Name: Anti-Particulate Guanylate Cyclase C Antibody (FITC)
Description: Rabbit polyclonal antibody to Particulate Guanylate Cyclase C (FITC)
Applications: CM, ELISA, ICC, IF, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:200; Immunofluorescence: 1:200; Immunohistochemistry: 1:200; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase C protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: FITC
Concentration: 0.75-1.20 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.
Tissue Specificity: Intestine and possibly at low levels in additional tissues.
Sequence Similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Post-Translational Modification: Glycosylation at Asn-74 and/or Asn-78 is required for interaction with VIP36 while glycosylation at Asn-401 modulates ligand-mediated GC-C activation.
Cellular Location: Cell membrane. Endoplasmic reticulum membrane.

The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
UniProt: P23897

Please Note: Anti-Particulate Guanylate Cyclase C Antibody (FITC) is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | PGCC-FITC
Size Price Quantity
100µg £475

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