Anti-Particulate Guanylate Cyclase C Antibody (FITC)
Rabbit polyclonal antibody to Particulate Guanylate Cyclase C (FITC) from FabGennix (PGCC-FITC).
|Name:||Anti-Particulate Guanylate Cyclase C Antibody (FITC)|
|Description:||Rabbit polyclonal antibody to Particulate Guanylate Cyclase C (FITC)|
|Applications:||CM, ELISA, ICC, IF, IHC, IP, WB|
|Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:200; Immunofluorescence: 1:200; Immunohistochemistry: 1:200; Western Blot: 1:500|
|Reactivity:||Human, Mouse, Rat|
|Immunogen:||Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase C protein.|
|Concentration:||0.75-1.20 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.|
|Tissue Specificity:||Intestine and possibly at low levels in additional tissues.|
|Sequence Similarities:||Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|
|Post-Translational Modification:||Glycosylation at Asn-74 and/or Asn-78 is required for interaction with VIP36 while glycosylation at Asn-401 modulates ligand-mediated GC-C activation.|
|Cellular Location:||Cell membrane. Endoplasmic reticulum membrane.
The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Please Note: Anti-Particulate Guanylate Cyclase C Antibody (FITC) is for research use only. It is not intended for diagnostic of therapeutic use.