Anti-PBX2 Antibody [PCRP-PBX2-1C4] (A277733)

Anti-PBX2 Antibody [PCRP-PBX2-1C4]

Mouse monoclonal [PCRP-PBX2-1C4] antibody to PBX2.

Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.

ELISA, IP, Flow Cytometry, IF

IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Recombinant full-length human PBX2 protein.

Mouse

Monoclonal

PCRP-PBX2-1C4

IgG2b

Protein A/G chromatography.

200 µg/ml

46 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-PBX2 Antibody [PCRP-PBX2-1C4] - BSA and Azide free (A278321).

G17, Homeobox 12, Homeobox protein PBX2, HOX12, OTTHUMP00000029151, PBX2MHC, pre B cell leukemia homeobox 2, Pre-B-cell leukemia transcription factor 2, Protein G17