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Anti-PDE11A Antibody (Biotin)

 
Rabbit polyclonal antibody to PDE11A (Biotin) from FabGennix (PD11A.112-BIOTIN).
Overview
Name: Anti-PDE11A Antibody (Biotin)
Description: Rabbit polyclonal antibody to PDE11A (Biotin)
Applications: CM, ELISA, ICC, IF, IHC, IP, WB
Dilutions: Confocal Microscopy: 1:250; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:250; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 420-480 on PDE11A protein, common to all PDE11A variants.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.68 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Tissue Specificity: Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
Involvement in Disease: Primary pigmented nodular adrenocortical disease 2: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family.
Cellular Location: Cytoplasm > Cytosol.
UniProt: Q9HCR9
Synonyms: 5''-cyclic-AMP and -GMP phosphodiesterase 11A Antibody
cAMP and cGMP phosphodiesterase 11A Antibody
cGMP phosphodiesterase 11A Antibody
Cyclic nucleotide phosphodiesterase 11A Antibody
Dual 3'' Antibody
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Antibody
pde11 Antibody
PDE11A1 Antibody
pde11a2 Antibody
PDE11_HUMAN Antibody
Phosphodiesterase 11A Antibody
PPNAD2 Antibody
Information: Target information shown above is from the UniProt Consortium.


Related Products
Description: Rabbit polyclonal antibody to PDE11A (Biotin)
Application: CM, ELISA, ICC, IF, IHC, IP, WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 100-150 on PDE11A protein, common to all PDE11A variants.

£475






Please Note: Anti-PDE11A Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | PD11A.112-BIOTIN
Size Price Quantity
100µg £475

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