Anti-Phospho-PDE10A Antibody (FITC)
|Name:||Anti-Phospho-PDE10A Antibody (FITC)|
|Description:||Rabbit polyclonal antibody to Phospho-PDE10A (FITC)|
|Applications:||ELISA, IP, WB|
|Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:200; Western Blot: 1:500|
|Reactivity:||Human, Monkey, Mouse, Rat|
|Immunogen:||Phosphorylated synthetic MAP common to all PDE10A variants. Taken within amino acid region 1-50 on human PDE10A protein.|
|Concentration:||0.7 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.|
|Tissue Specificity:||Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.|
|Involvement in Disease:||Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
|Sequence Similarities:||Belongs to the cyclic nucleotide phosphodiesterase family.|
|Post-Translational Modification:||Isoform PDE10A2: Phosphorylated on Thr-16.|
Located mostly to soluble cellular fractions.