Anti-Phospho-STAT4 Antibody (FITC)
|Name:||Anti-Phospho-STAT4 Antibody (FITC)|
|Description:||Rabbit polyclonal antibody to Phospho-STAT4 (FITC)|
|Applications:||ELISA, IP, WB|
|Dilutions:||ELISA: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Western Blot: 1:500|
|Reactivity:||Human, Mouse, Rat|
|Immunogen:||Synthetic peptide taken within amino acid region 690-740 on human Signal transudcer and activator of transcription 4 protein. Phosphorylated serine 721 residue.|
|Concentration:||0.5 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.|
|Involvement in Disease:||Systemic lupus erythematosus 11: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
|Sequence Similarities:||Belongs to the transcription factor STAT family.|
|Post-Translational Modification:||Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).|
|Cellular Location:||Cytoplasm. Nucleus.
Translocated into the nucleus in response to phosphorylation.