Anti-PI 3 Kinase p110 delta Antibody [PIK3CD/4639] (A315517)

Anti-PI 3 Kinase p110 delta Antibody [PIK3CD/4639]

Mouse monoclonal [PIK3CD/4639] antibody to PI 3 Kinase p110 delta.

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85a and p85b), each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110a and p110b interact with p85a, and p110a has also been shown to interact with p85b in vitro. It has been shown to bind p85a and b, but it apparently does not phosphorylate these subunits. p110d has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly, p110g does not interact with the p85 subunits and has been shown to be activated by a and bg heterotrimeric G proteins. Two p110d isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus, lung and spleen tissues.

WB, IHC-P

THP1 cells. Human spleen, lymph node or tonsil

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant fragment of human PIK3CD protein (around Amino Acids 520-720). The exact sequence is proprietary.

Mouse

Monoclonal

PIK3CD/4639

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

119 kDa / 33 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, 5-bisphosphate 3-kinase catalytic subunit delta isoform, APDS, GRB1, IMD14, p110d, p110delta, p110dp85a, p85-ALPHA, Phosphatidylinositol 3 kinase catalytic delta polypeptide, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta, Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta, Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform, Phosphatidylinositol-4, Phosphoinositide 3 kinase B, Phosphoinositide 3 kinase C, Phosphoinositide 3 kinase catalytic delta polypeptide, Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta, PI3 kinase p110 subunit delta, PI3-kinase subunit delta, PI3K, PI3K-delta, PI3Kdelta, Pik3cd, PIK3R1, PK3CD, PK3CD_HUMAN, PtdIns 3 kinase p110, PtdIns 3 kinase subunit p110 delta, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit p110-delta