Anti-Pit1 Antibody [PIT1/7262] (A315518)

Anti-Pit1 Antibody [PIT1/7262]

Mouse monoclonal [PIT1/7262] antibody to Pit1.

Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

Human pituitary or tonsil.

IHC: 1:10-1:20

Human

Recombinant human full-length POU1F1 protein.

Mouse

Monoclonal

PIT1/7262

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

31-35 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Dwarf, GHF 1, GHF 1A, GHF-1, GHF1, GHF1A, Growth hormone factor 1, Hmp 1, Hmp1, Pit 1, Pit 1 beta, PIT 1Z, PiT-1, Pit1 beta, PIT1Z, PIT1_HUMAN, Pituitary growth hormone, Pituitary specific positive transcription factor 1, Pituitary-specific positive transcription factor 1, POU class 1 homeobox 1, POU domain class 1 transcription factor 1, POU domain transcriptional regulator, POU1F1