Anti-PMS1 Antibody [PCRP-PMS1-2E11] - BSA and Azide free (A278340)

Mouse monoclonal [PCRP-PMS1-2E11] antibody to PMS1 for ELISA, IP, Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-PMS1 Antibody [PCRP-PMS1-2E11] - BSA and Azide free
Description
Mouse monoclonal [PCRP-PMS1-2E11] antibody to PMS1.
Specificity
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
Applications
ELISA, IP, Flow Cytometry, IF
Dilutions
Flow Cytometry: 1-2 µg/million cells, IP: 1-2µg / 100-500µg proteins, IF: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human PMS1 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-PMS1-2E11
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
105.8 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-PMS1 Antibody [PCRP-PMS1-2E11] (A277752).
Synonyms
DNA mismatch repair protein PMS1, FLJ98259, HNPCC3, hPMS1, Human homolog of yeast mutL, Mismatch repair gene PMSL1, PMS1 postmeiotic segregation increased 1, PMS1 postmeiotic segregation increased 1 (S. cerevisiae), PMS1 protein homolog 1, PMS1_HUMAN, PMSL1, Rhabdomyosarcoma antigen MU RMS 40.10B, Rhabdomyosarcoma antigen MU RMS 40.10E
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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