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Anti-Podoplanin Antibody (Biotin)

 
Rabbit polyclonal antibody to Podoplanin (Biotin) from FabGennix (PDPN.n-BIOTIN).
Overview
Name: Anti-Podoplanin Antibody (Biotin)
Description: Rabbit polyclonal antibody to Podoplanin (Biotin)
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Monkey, Mouse
Immunogen: Synthetic peptide taken within amino acid region 30-100 on human Podoplanin protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
Tissue Specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
Sequence Similarities: Belongs to the podoplanin family.
Post-Translational Modification: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
Cellular Location: Membrane. Cell projection > Filopodium membrane. Cell projection > Lamellipodium membrane. Cell projection > Microvillus membrane. Cell projection > Ruffle membrane.

Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
UniProt: Q86YL7
Synonyms: Aggrus Antibody
Glycoprotein 36 Antibody
Glycoprotein 36 KD Antibody
gp 36 Antibody
GP 38 Antibody
GP 40 Antibody
gp36 Antibody
GP38 Antibody
GP40 Antibody
HT1A 1 Antibody
HT1A1 Antibody
hT1alpha 1 Antibody
hT1alpha 2 Antibody
hT1alpha1 Antibody
hT1alpha2 Antibody
Lung type I cell membrane associated glycoprotein Antibody
Lung type I cell membrane associated glycoprotein isoform a Antibody
Lung type I cell membrane associated glycoprotein T1A 2 Antibody
OTS 8 Antibody
OTS8 Antibody
OTTHUMP00000009640 Antibody
OTTHUMP00000044504 Antibody
PA2.26 Antibody
PA2.26 antigen Antibody
Pdpn Antibody
PDPN_HUMAN Antibody
Podoplanin / gp36 Antibody
PSEC0003 Antibody
PSEC0025 Antibody
T1 alpha Antibody
T1 ALPHA GENE Antibody
T1-alpha Antibody
T1A Antibody
T1A 2 Antibody
TI1A Antibody
TIA 2 Antibody
TIA2 Antibody
Information: Target information shown above is from the UniProt Consortium.


Related Products
Description: Rabbit polyclonal antibody to Podoplanin (Biotin)
Application: ELISA, IHC, IP, WB
Host: Rabbit
Reactivity: Human, Monkey, Mouse
UniProt: Q86YL7

£429






Please Note: Anti-Podoplanin Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | PDPN.n-BIOTIN
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100µg £429

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