Anti-PPAR gamma Antibody (A283080)

Anti-PPAR gamma Antibody

Rabbit polyclonal antibody to PPAR gamma.

This antibody recognises human peroxisome proliferator-activated receptor ? (PPARG), a member of the nuclear hormone receptor subfamily of transcription factors. Upon activation, PPARG forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARG is principally involved in the cellular assimilation of lipids, with key roles in adipocyte differentiation and adipogenesis.Two alternatively spliced isoforms of PPARG exist, termed PPARG1 and PPARG2, which are identical except for an additional 30 amino acids at the N-terminus of PPARG2. This results in a predominant adipocyte localisation for PPARG2, whilst PPARG1 is ubiquitously expressed.PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.

ELISA: 1:8,000 - 1:32,000

Human, Mouse, Dog, Hamster, Rabbit, Mink, Rat, Guinea Pig, Macaque, Duck

Synthetic peptide corresponding to amino acids 255-268 of human PPAR gamma isoform 1.

PLTKAKARAILTGK

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit antii Human PPAR gamma antibody detects human peroxisome proliferator-activated receptor ? (PPARG), a member of the nuclear hormone receptor subfamily of transcription factors. Upon activation, PPARG forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARG is principally involved in the cellular assimilation of lipids, with key roles in adipocyte differentiation and adipogenesis.Two alternatively spliced isoforms of PPARG exist, termed PPARG1 and PPARG2, which are identical except for an additional 30 amino acids at the N-terminus of PPARG2. This results in a predominant adipocyte localisation for PPARG2, whilst PPARG1 is ubiquitously expressed.PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.

NR1C3, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG