Vault proteins are large, ribonucleoprotein (containing both RNA and protein components) complexes found in the cytoplasm of eukaryotic cells. They are composed of multiple copies of three main components: the major vault protein (MVP), the vault poly (ADP-ribose) polymerase (VPARP), and a small untranslated RNA molecule known as vault RNAs (vRNAs). The name "vault" is derived from the vault-like tertiary structure that these complexes form. Although the exact function of vaults is still not completely understood, they have been implicated in various cellular processes relevant to cancer, including transport of drug molecules within the cell, regulation of signalling pathways, and the development of drug resistance. In cancer, vault proteins have been the subject of significant research due to their strong association with tumour progression and chemotherapy resistance. Vaults have been found to play a role in multidrug resistance, a major challenge in cancer treatment. Studies have shown that increased expression of vault proteins correlates with resistance to chemotherapy drugs such as cisplatin and doxorubicin. Vaults may facilitate drug resistance by sequestering chemotherapy agents away from their target sites, or possibly by promoting drug efflux from cancer cells. Vault proteins have also been implicated in various signalling pathways associated with cancer progression. For example, the MVP component of vaults has been shown to interact with signalling molecules such as protein kinase C (PKC) and with extracellular signal-regulated kinase (ERK), which are involved in cell growth and survival. These interactions suggest that vaults may also influence oncogenic signalling cascades. Elevated levels of vault proteins, particularly MVP, have been observed in several types of cancer, including lung, breast, ovarian, and pancreatic cancers. Increased expression of vault proteins has been associated with poor prognosis and reduced patient survival rates, making them potential prognostic markers for certain cancers. We offer a wide product catalogue of research tools for studying vault proteins, including MVP antibodies. Explore our full vault proteins product range below and discover more, for less.