+44 (0)1223 298875

Anti-REST / NRSF Antibody (Biotin)

 
Rabbit polyclonal antibody to REST / NRSF (Biotin) from FabGennix (REST-BIOTIN).
Overview
Name: Anti-REST / NRSF Antibody (Biotin)
Description: Rabbit polyclonal antibody to REST / NRSF (Biotin)
Applications: ELISA, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 1000-1097 on human REST protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.52-0.54 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
Tissue Specificity: Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary.
Involvement in Disease: Wilms tumor 6: A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells.
Cellular Location: Nucleus.

Colocalizes with ZFP90 in the nucleus.
UniProt: Q13127
Gene ID:
Synonyms: Neural Restrictive Silencer Factor Antibody
Neural-restrictive silencer factor Antibody
Neuron Restrictive Silencer Factor Antibody
NRSF Antibody
RE1 silencing transcription factor Antibody
RE1-silencing transcription factor Antibody
Repressor binding to the X2 box Antibody
REST / NRSF Antibody
REST protein Antibody
REST_HUMAN Antibody
X2 box repressor Antibody
XBR Antibody
Information: Target information shown above is from the UniProt Consortium.


Please Note: Anti-REST / NRSF Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | REST-BIOTIN
Size Price Quantity
100µg £429

or
Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 5-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe