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Anti-SCN2A Antibody

Rabbit polyclonal antibody to SCN2A from ABclonal (A10574).
Name: Anti-SCN2A Antibody
Description: Rabbit polyclonal antibody to SCN2A.
Applications: WB
Dilutions: WB: 1:1000 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human SCN2A.
Protein Length: 2005
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Involvement in Disease: Seizures, benign familial infantile, 3: A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS3 inheritance is autosomal dominant.

Epileptic encephalopathy, early infantile, 11: An autosomal dominant seizure disorder characterized by neonatal or infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG.
Sequence Similarities: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily.
Post-Translational Modification: May be ubiquitinated by NEDD4L; which would promote its endocytosis.
Cellular Location: Cell membrane.
UniProt: Q99250
Gene ID: 6326
Synonyms: HBSC II Antibody
NAC2 Antibody
SCN2A1 Antibody
SCN2A2 Antibody
SCN2A_HUMAN Antibody
Sodium channel protein brain II subunit alpha Antibody
Sodium channel protein type 2 subunit alpha Antibody
Sodium channel protein type II subunit alpha Antibody
Sodium channel protein, brain II subunit alpha Antibody
Voltage gated sodium channel subunit alpha Nav1.2 Antibody
Voltage-gated sodium channel subunit alpha Nav1.2 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cells, using SCN2A antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to SCN2A
Application: IHC
Host: Rabbit
Reactivity: Human, Rat
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human sodium channel, voltage-gated, type II, alpha subunit

£234

Please Note: Anti-SCN2A Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10574
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £20 to United Kingdom
  • £35 to Europe