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Anti-SERPINA5 Antibody

Rabbit polyclonal antibody to SERPINA5 from ABclonal (A1036).
Name: Anti-SERPINA5 Antibody
Description: Rabbit polyclonal antibody to SERPINA5.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human
Immunogen: A synthetic Peptide of human SERPINA5.
Protein Length: 406
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
Tissue Specificity: Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate.
Sequence Similarities: Belongs to the serpin family.
Post-Translational Modification: N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid residues.
Cellular Location: Secreted > Extracellular space.

Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
UniProt: P05154
Gene ID: 5104
Synonyms: Acrosomal serine protease inhibitor Antibody
IPSP Antibody
IPSP_HUMAN Antibody
PAI 3 Antibody
PAI-3 Antibody
PAI3 Antibody
PCI Antibody
PCI-B Antibody
PLANH 3 Antibody
PLANH3 Antibody
Plasma serine protease inhibitor Antibody
Plasminogen activator inhibitor 3 Antibody
Plasminogen activator inhibitor III Antibody
PROCI Antibody
Protein C inhibitor Antibody
Serpin A5 Antibody
Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5 Antibody
Serpin peptidase inhibitor clade A member 5 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of liver cell lysate using SERPINA5 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to SERPINA5
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

£234

Description: Rabbit polyclonal antibody to PAI-3 (L291)
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide, corresponding to amino acids 261-310 of Human PAI-3.

£165 – £283

Description: Rabbit polyclonal antibody to Serpin A5
Application: WB
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human Serpin A5.

£180 – £234

Description: Mouse Monoclonal Antibody to Protein C inhibitor
Application: ELISA, WB
Host: Mouse
Isotype: IgG1
Immunogen: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

£284





Please Note: Anti-SERPINA5 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A1036
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £35 to Europe