Anti-SH3GL2 Antibody (A283709)

Anti-SH3GL2 Antibody

Rabbit polyclonal antibody to SH3GL2.

This antibody recognises endophilin-A1, also known as SH3 domain protein 2A, SH3 domain protein 2A and EEN-B1. Endophilins belong to the family of Bin/Amphiphysin/Rvs (BAR) proteins and are composed of an N-terminal BAR domain and a C-terminal SH3 domain. Endophilin-A1 is essential for synaptic vesicle endocytosis. Its interaction with ataxin-2 and huntingtin is important for plastin-associated cellular pathways. Endophilin-A1 is also involved in regulation of blood-brain barrier permeability through the EGFR-JNK signaling pathway.

WB: 1:500 - 1:2,000

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human endophilin-A1.

MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDS

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 42 kDa in various cell lysates under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti endophilin-A1 antibody recognizes endophilin-A1, also known as SH3 domain protein 2A, SH3 domain protein 2A and EEN-B1. Endophilins belong to the family of Bin/Amphiphysin/Rvs (BAR) proteins and are composed of an N-terminal BAR domain and a C-terminal SH3 domain (Safari and Suetsugu 2012). Endophilin-A1 is essential for synaptic vesicle endocytosis (Llobet et al. 2011). Its interaction with ataxin-2 and huntingtin is important for plastin-associated cellular pathways (Ralser et al. 2005). Endophilin-A1 is also involved in regulation of blood-brain barrier permeability through the EGFR-JNK signaling pathway (Chen et al. 2015).

bA335L15.1 (SH3 domain GRB2 like 2), CNSA2, EEN B1, EEN-B1, Endophilin 1, Endophilin A1, Endophilin A1 BAR domain, Endophilin-1, Endophilin-A1, FLJ20276, FLJ25015, OTTHUMP00000021084, SH3 domain containing GRB2 like protein 2, SH3 domain GRB2 like 2, SH3 domain protein 2A, SH3 domain-containing GRB2-like protein 2, SH3D2A, SH3G2_HUMAN, Sh3p4, SH3PA