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Anti-SMAD7 Antibody

Rabbit polyclonal antibody to SMAD7 from ABclonal (A1051).
Name: Anti-SMAD7 Antibody
Description: Rabbit polyclonal antibody to SMAD7.
Applications: WB
Dilutions: WB: 1:500 - 1:1000.
Reactivity: Human
Immunogen: Recombinant protein of human SMAD7.
Protein Length: 426
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Tissue Specificity: Ubiquitous with higher expression in the lung and vascular endothelium.
Involvement in Disease: Colorectal cancer 3: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Sequence Similarities: Belongs to the dwarfin/SMAD family.
Post-Translational Modification: Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.
Cellular Location: Nucleus. Cytoplasm.

Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236).
UniProt: O15105
Gene ID: 4092
Synonyms: CRCS3 Antibody
FLJ16482 Antibody
hSMAD 7 Antibody
hSMAD7 Antibody
MAD Antibody
MAD (mothers against decapentaplegic Drosophila) homolog 7 Antibody
Mad homolog 7 Antibody
MAD homolog 8 Antibody
MAD mothers against decapentaplegic homolog 7 Antibody
MADH 7 Antibody
MADH 8 Antibody
MADH6 Antibody
MADH7 Antibody
MADH8 Antibody
Mothers Against Decapentaplegic Drosophila Homolog of 6 Antibody
Mothers Against Decapentaplegic Drosophila Homolog of 7 Antibody
Mothers against decapentaplegic homolog 7 Antibody
Mothers against decapentaplegic homolog 8 Antibody
Mothers against DPP homolog 7 Antibody
Mothers against DPP homolog 8 Antibody
SMA- AND MAD-RELATED PROTEIN 7 Antibody
SMAD Antibody
SMAD 7 Antibody
SMAD family member 7 Antibody
SMAD, mothers against DPP homolog 7 Antibody
SMAD, mothers against DPP homolog 7 (Drosophila) Antibody
SMAD6 Antibody
SMAD7_HUMAN Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of SW480 cells, using SMAD7 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (5)
Description: Rabbit polyclonal antibody to Smad7
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human Smad7.

£165 – £283

Total Citations (1)
Description: Rabbit polyclonal antibody to Smad6 (N372)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 341-390 of Human Smad6.

£165 – £283

Description: Rabbit polyclonal antibody to SMAD7
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human SMAD family member 7

£234

Description: Rabbit polyclonal antibody to SMAD6.
Application: WB
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Please Note: Anti-SMAD7 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A1051
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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