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Anti-SMURF2 Antibody

Rabbit polyclonal antibody to SMURF2 from ABclonal (A10592).
Name: Anti-SMURF2 Antibody
Description: Rabbit polyclonal antibody to SMURF2.
Applications: WB
Dilutions: WB: 1:1000 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human SMURF2.
Protein Length: 748
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Tissue Specificity: Widely expressed.
Post-Translational Modification: Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.
Cellular Location: Nucleus. Cytoplasm. Cell membrane. Membrane raft.

Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts.
UniProt: Q9HAU4
Gene ID: 64750
Synonyms: E3 ubiquitin-protein ligase SMURF2 Antibody
EC 6.3.2. Antibody
hSMURF2 Antibody
MGC138150 Antibody
Smad specific E3 ubiquitin ligase 2 Antibody
SMAD specific E3 ubiquitin protein ligase 2 Antibody
SMAD ubiquitination regulatory factor 2 Antibody
SMAD-specific E3 ubiquitin-protein ligase 2 Antibody
SMUF2_HUMAN Antibody
SMURF 2 Antibody
Ubiquitin protein ligase SMURF2 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of SW480 cells, using SMURF2 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to SMURF2
Application: IHC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human SMAD specific E3 ubiquitin protein ligase 2


Please Note: Anti-SMURF2 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10592
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £20 to United Kingdom
  • £35 to Europe