Anti-Spastin Antibody [Sp 6C6] (A250022)

Mouse monoclonal [Sp 6C6] antibody to Spastin for IF and WB.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Spastin Antibody [Sp 6C6]
Description
Mouse monoclonal [Sp 6C6] antibody to Spastin.
Specificity
The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs.
Applications
IF, WB
Dilutions
IF: 1-2 µg/ml, IHC: 1-2 µg/ml
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full-length human Spastin protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
Sp 6C6
Isotype
IgG2a
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
52 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Spastin Antibody [Sp 6C6] - BSA and Azide free (A253202).
Synonyms
ADPSP, FSP 2, FSP2, KIAA1083, Spast, Spastic paraplegia 4, spastic paraplegia 4 (autosomal dominant; spastin), SPG 4, SPG4, SPG4 gene
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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