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Anti-STIL Antibody

Rabbit polyclonal antibody to STIL from ABclonal (A10350).
Name: Anti-STIL Antibody
Description: Rabbit polyclonal antibody to STIL.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human
Immunogen: Recombinant protein of human STIL.
Protein Length: 1287
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124).
Tissue Specificity: Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer.
Involvement in Disease: Microcephaly 7, primary, autosomal recessive: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Post-Translational Modification: Ubiquitinated.
Cellular Location: Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole.
UniProt: Q15468
Gene ID: 6491
Synonyms: DKFZp686O09161 Antibody
MCPH7 Antibody
OTTHUMP00000009566 Antibody
SCL interrupting locus protein Antibody
SCL-interrupting locus protein Antibody
SCL/TAL1 interrupting locus Antibody
SIL Antibody
STIL_HUMAN Antibody
TAL 1 interrupting locus protein Antibody
TAL-1-interrupting locus protein Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cell lines, using STIL antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Please Note: Anti-STIL Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10350
Size Price Quantity
50µl £148
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe