Anti-Surfactant Protein D / SP-D Antibody [1.7] (A278700)

Anti-Surfactant Protein D / SP-D Antibody [1.7]

Mouse monoclonal [1.7] antibody to Surfactant Protein D / SP-D.

This antibody recognises porcine surfactant protein D (pSP-D), a ~138 kDa member of the collectin family of proteins. Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. pSP-D may serve as a serum biomarker specific for bronchopneumonia in pigs.

WB, IHC-P, IHC-Fr, IF

IHC-Fr: 1 µg/ml

Porcine

Purified porcine surfactant protein D.

Mouse

Monoclonal

1.7

IgG1

1 mg/ml

Approximately 138 kDa.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Porcine surfactant protein D antibody, clone 1.7 detects porcine surfactant protein D (pSP-D), a ~138 kDa member of the collectin family of proteins. Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. pSP-D may serve as a serum biomarker specific for bronchopneumonia in pigs (Kahlisch et al. 2009).