Anti-TCR gamma/delta Antibody [B1] (PE) (A279737)

Anti-TCR gamma/delta Antibody [B1] (PE)

Mouse monoclonal [B1] antibody to TCR gamma/delta (PE).

This antibody recognises TCR gamma/delta, a T cell receptor expressed by a small subset of T cells. In healthy individuals these TCR gamma/delta cells account for 1-10% of peripheral blood lymphocytes. TCR gamma/delta is composed of disulfide bonded gamma and delta chains that can bind directly to pathogen derived glycoprotein's or non-classical MHC molecules on tumor cells. This clone B1 has been used as a blocking antibody in experiments to examine the recognition of tumor cells by TCR gamma/delta cells. These experiments supported the hypothesis that innate NK receptors on gamma/delta cells can also bind and recognize tumor cells.

Flow Cytometry: Neat, Use 5ul of the suggested working dilution to label 1x10⁶ cells in 100µl

Human, Primate

Mouse

Monoclonal

B1

IgG1

Protein A affinity chromatography of tissue culture supernatant.

Lot Specific

>95% (by SDS-PAGE).

Liquid

Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Mouse anti Human TCR gamma/delta, clone B1 recognizes TCR gamma/delta, a T cell receptor expressed by a small subset of T cells. In healthy individuals these TCR gamma/delta cells account for 1-10% of peripheral blood lymphocytes (Gomes et al. 2010). TCR gamma/delta is composed of disulfide bonded gamma and delta chains that can bind directly to pathogen derived glycoprotein's or non-classical MHC molecules on tumor cells (Kuhns et al. 2006). This clone B1 has been used as a blocking antibody in experiments to examine the recognition of tumor cells by TCR gamma/delta cells. These experiments supported the hypothesis that innate NK receptors on gamma/delta cells can also bind and recognize tumor cells (Correia et al. 2011).

This product is for research use only. It is not intended for diagnostic or therapeutic use.