Recombinant Anti-Thyroglobulin Antibody [TGB/1970R] (A250112)

Recombinant rabbit monoclonal [TGB/1970R] antibody to Thyroglobulin for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Thyroglobulin Antibody [TGB/1970R]
Description
Recombinant rabbit monoclonal [TGB/1970R] antibody to Thyroglobulin.
Specificity
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Cross Reactivity
This antibody does not cross react with Mouse or Rat.
Immunogen
Recombinant full-length human Thyroglobulin protein.
Host
Rabbit
Clonality
Monoclonal
Clone ID
TGB/1970R
Isotype
IgG
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
660 kDa (dimeric Form)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Thyroglobulin Antibody [TGB/1970R] - BSA and Azide free (A253292).
Synonyms
AITD 3, AITD3, hTG, TDH3, Tg, TGN, THYG_HUMAN
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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