Recombinant Anti-TIA1 Antibody [TIA1/1352R] (A278071)

Anti-TIA1 Antibody [TIA1/1352R]

Recombinant rabbit monoclonal [TIA1/1352R] antibody to TIA1.

The T cell intracellular antigen 1 (TIA 1) is a 17 kDa cytoplasmic granule associated protein also designated as GMP 17, for granule membrane protein of 17 kDa. The GMP 17/TIA 1 molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) mediated apoptosis. Within hematopoietic cell lines, the TIA1/1352R monoclonal antibody reacts with about 90% of CD16+, 50 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

IHC-P: 1-2 µg/ml

Human

Human bone marrow malignant cells from a non B, non T acute leukemia.

Rabbit

Monoclonal

TIA1/1352R

IgG

Protein A chromatography.

200 µg/ml

40 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TIA1 Antibody [TIA1/1352R] - BSA and Azide free (A278659).

Cytotoxic granule associated RNA binding protein, Cytotoxic granule associated RNA binding protein 1, mTIA-1, Nucleolysin TIA 1 isoform p40, Nucleolysin TIA-1 isoform p40, Nucleolysin TIA1 isoform p40, p40 TIA 1, p40-TIA-1, p40-TIA-1 (containing p15-TIA-1), RNA binding protein TIA 1, RNA binding protein TIA1, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, Tia, TIA 1, TIA 1 cytotoxic granule associated RNA binding protein, TIA-1, TIA1 cytotoxic granule associated RNA binding protein, TIA1 cytotoxic granule associated RNA binding protein like 1, TIA1 protein, TIA1_HUMAN, TIAL1, TIAR, WDM