Anti-TIGIT Antibody [TIGIT/3017] (A248428)

Mouse monoclonal [TIGIT/3017] antibody to TIGIT for ELISA, Flow Cytometry and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-TIGIT Antibody [TIGIT/3017]
Description
Mouse monoclonal [TIGIT/3017] antibody to TIGIT.
Specificity
TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
Applications
ELISA, Flow Cytometry, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 22-141, of human TIGIT protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
TIGIT/3017
Isotype
IgG2c
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
26 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TIGIT Antibody [TIGIT/3017] - BSA and Azide free (A251610).
Synonyms
DKFZp667A205, ENSMUSG00000071552, FLJ39873, RGD1563191, T cell immunoreceptor with Ig and ITIM domains, TIGIT_HUMAN, V-set and immunoglobulin domain containing 9, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain containing 3, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3, Washington University cell adhesion molecule, WUCAM
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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