Anti-TRAF1 Antibody [TRAF1/2770] - BSA and Azide free (A253392)

Name: Anti-TRAF1 Antibody [TRAF1/2770] - BSA and Azide free
Brand: Antibodies.com
SKU: A253392
Price: 525.0 USD
Availability: InStock

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$525

Mouse monoclonal [TRAF1/2770] antibody to TRAF1 for IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

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Telephone

+1 (314) 370-6046

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Monospecific Antibody

Specifications

Name

Anti-TRAF1 Antibody [TRAF1/2770] - BSA and Azide free

Description

Mouse monoclonal [TRAF1/2770] antibody to TRAF1.

Specificity

This antibody recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant fragment, around amino acids 73-219, of human TRAF1 protein. The exact sequence is proprietary.

Host

Mouse

Clonality

Monoclonal

Clone ID

TRAF1/2770

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Molecular Weight

52 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-TRAF1 Antibody [TRAF1/2770] (A250212).

Synonyms

4732496E14Rik, EBI6, EBV induced protein 6, Epstein-Barr virus-induced protein 6, MGC:10353, Tnf receptor associated factor 1, TNF receptor-associated factor 1, TRAF 1, TRAF1_HUMAN

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (3)

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Figure 1: Immunohistochemistry - Anti-TRAF1 Antibody [TRAF1/2770] - BSA and Azide free (A253392)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human spleen using Anti-TRAF1 Antibody [TRAF1/2770].

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Figure 2: Immunohistochemistry - Anti-TRAF1 Antibody [TRAF1/2770] - BSA and Azide free (A253392)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lymph node using Anti-TRAF1 Antibody [TRAF1/2770].

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Figure 3: Anti-TRAF1 Antibody [TRAF1/2770] - BSA and Azide free (A253392)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-TRAF1 Antibody [TRAF1/2770]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

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