Anti-TrkB Antibody [NTRK2/4673] (A315753)

Anti-TrkB Antibody [NTRK2/4673]

Mouse monoclonal [NTRK2/4673] antibody to TrkB.

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by NTRK2, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.

Human brain tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 250-450) of human NTRK2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

NTRK2/4673

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

95-145 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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