+44 (0)1223 298875

Anti-TRPM4 Antibody

Rabbit polyclonal antibody to TRPM4 from ABclonal (A10146).
Name: Anti-TRPM4 Antibody
Description: Rabbit polyclonal antibody to TRPM4.
Applications: WB
Dilutions: WB: 1:200 - 1:1000.
Reactivity: Human
Immunogen: Recombinant protein of human TRPM4.
Protein Length: 1214
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Tissue Specificity: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.
Involvement in Disease: Progressive familial heart block 1B: A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Sequence Similarities: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.
Post-Translational Modification: Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).
Cellular Location: Cell membrane. Endoplasmic reticulum. Golgi apparatus.
UniProt: Q8TD43
Gene ID: 54795
Synonyms: 1110030C19Rik Antibody
AW047689 Antibody
Calcium-activated non-selective cation channel 1 Antibody
FLJ20041 Antibody
hTRPM4 Antibody
Long transient receptor potential channel 4 Antibody
LTrpC-4 Antibody
LTrpC4 Antibody
Melastatin 4 Antibody
Melastatin like 2 protein Antibody
Melastatin-4 Antibody
Melastatin-like 2 Antibody
Mls2s Antibody
PFHB1B Antibody
Transient receptor potential cation channel subfamily M member 4 Antibody
Transient receptor potential cation channel, subfamily M, member 4 Antibody
TRPM4B Antibody
TRPM4_HUMAN Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of various cells, using TRPM4 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Please Note: Anti-TRPM4 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A10146
Size Price Quantity
50µl £148
100µl £243
200µl £372

or
Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe