Anti-beta Tubulin Antibody [TU-13] (A281849)

Anti-beta Tubulin Antibody [TU-13]

Mouse monoclonal [TU-13] antibody to beta Tubulin.

This antibody recognises an epitope within the N-terminal region of tubulin beta, a ~50 kDa globular protein and major constituent of microtubules within the cytoskeleton, involved in meiosis, mitosis, intracellular transport and maintaining cell shape.The evolutionarily conserved heterodimer tubulin, made up of a tubulin alpha and beta chain, binds two molecules of GTP, one at a non-exchangeable site on the alpha chain and one at an exchangeable site on the beta chain. Only the beta chain possesses GTPase activity however, hydrolysing GTP to GDP, and influencing the stability of the dimer within the microtubule. Mouse anti Pig tubulin beta antibody, clone TU-13 partially inhibits microtubule assembly in vitro (Draber, P. et al.). Mouse anti Pig Tubulin beta antibody, clone TU-13 has also been successfully employed for the demonstration of neuronal cells in mouse brain by immunohistochemistry on floating sections (Nováková et al. 1997).

ELISA, IHC-Fr, WB

WB: 1 µg/ml

Porcine, Human, Plants, Mouse, Rat

Tubulin beta from porcine brain.

Mouse

Monoclonal

TU-13

IgM

1 mg/ml

Approximately 50 kDa in human RAJI and mouse EL4 cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Pig tubulin beta antibody, clone TU-13 recognizes an epitope within the N-terminal region (NT) of tubulin beta, a ~50 kDa globular protein and major constituent of microtubules within the cytoskeleton, involved in meiosis, mitosis, intracellular transport and maintaining cell shape.The evolutionarily conserved heterodimer tubulin, made up of a tubulin alpha and beta chain, binds two molecules of GTP, one at a non-exchangeable site on the alpha chain and one at an exchangeable site on the beta chain. Only the beta chain possesses GTPase activity however, hydrolysing GTP to GDP, and influencing the stability of the dimer within the microtubule.Mouse anti Pig tubulin beta antibody, clone TU-13 partially inhibits microtubule assembly in vitro (Draber, P. et al.). Mouse anti Pig Tubulin beta antibody, clone TU-13 has also been successfully employed for the demonstration of neuronal cells in mouse brain by immunohistochemistry on floating sections (Nováková et al. 1997).

TUBB, TUBB5, Tubulin beta chain, Tubulin beta-5 chain