Anti-Visfatin Antibody (Biotin)
Rabbit polyclonal antibody to Visfatin (Biotin) from FabGennix (VSFTN.c-BIOTIN).
|Name:||Anti-Visfatin Antibody (Biotin)|
|Description:||Rabbit polyclonal antibody to Visfatin (Biotin)|
|Applications:||ELISA, IHC, IP, WB|
|Dilutions:||DB: 1:4,000; DB: 1:4,000; ELISA: 1:4,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500|
|Immunogen:||C-epitope synthetic peptide taken within amino acid region 400-490 on human Visfatin protein.|
|Concentration:||0.68-0.70 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
|Function:||Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).|
|Tissue Specificity:||Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.|
|Sequence Similarities:||Belongs to the NAPRTase family.|
|Cellular Location:||Nucleus. Cytoplasm. Secreted.
Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
EC 184.108.40.206 Antibody
Nicotinamide phosphoribosyltransferase Antibody
PBEF 1 Antibody
Pre B cell colony enhancing factor Antibody
Pre B cell colony enhancing factor 1 Antibody
Pre B cell enhancing factor Antibody
Pre-B cell-enhancing factor Antibody
Pre-B-cell colony-enhancing factor 1 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-Visfatin Antibody (Biotin) is for research use only. It is not intended for diagnostic of therapeutic use.