Anti-VPS34 Antibody (A283308)

Anti-VPS34 Antibody

Rabbit polyclonal antibody to VPS34.

This antibody recognises Phosphatidylinositol 3-kinase catalytic subunit type 3, also known as VPS34 (vacuolar protein sorting 34), PI3-kinase type 3 or PIK3C3. VPS34 is a ubiquitously expressed class III PI3K (phosphoinositide 3-kinase), and member of the PI3/PI4-kinase family, which utilizes phosphatidylinositol (PtdIn) as a substrate, and functions as the catalytic subunit of the PI3K complex.VPS34 plays a role in the transport of lysosomal enzyme precursors to lysosomes, and in endocytosis and vesicular trafficking, and has been strongly implicated as a regulator of autophagy, forming a multi-protein complex with the proautophagic tumor suppressors Beclin1/Atg6, Bif-1, and UVRAG, in the initiation of autophagosome formation. Distinct complexes of VPS34 regulates endocytic processes vital for late-stage autophagosome-lysosome fusion.

WB, IF

IF: 1:100, WB: 2.0 - 4.0 µg/ml

Human, Mouse, Rat

Synthetic peptide corresponding to amino acids 22-34 of human VPS34, conjugated to Keyhole Limpet Haemocyanin. The corresponding sequence is identical in mouse and rat.

KIGSLEGKREQKS

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 105 kDa in HEK-293T cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti VPS34 antibody recognises Phosphatidylinositol 3-kinase catalytic subunit type 3, also known as VPS34 (vacuolar protein sorting 34), PI3-kinase type 3 or PIK3C3. VPS34 is a ubiquitously expressed class III PI3K (phosphoinositide 3-kinase), and member of the PI3/PI4-kinase family, which utilizes phosphatidylinositol (PtdIn) as a substrate, and functions as the catalytic subunit of the PI3K complex.VPS34 plays a role in the transport of lysosomal enzyme precursors to lysosomes, and in endocytosis and vesicular trafficking, and has been strongly implicated as a regulator of autophagy, forming a multi-protein complex with the proautophagic tumor suppressors Beclin1/Atg6, Bif-1, and UVRAG, in the initiation of autophagosome formation. Distinct complexes of VPS34 regulates endocytic processes vital for late-stage autophagosome-lysosome fusion.

hVps34, MGC61518, Phosphatidylinositol 3 kinase catalytic subunit type 3, Phosphatidylinositol 3 kinase class 3, Phosphatidylinositol 3 kinase p100 subunit, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide 3 kinase class 3, Phosphoinositide-3-kinase class 3, PI 3 Kinase Class 3, PI3 kinase type 3, PI3-kinase type 3, PI3K type 3, Pik3c3, PK3C3_HUMAN, PtdIns 3 kinase type 3, PtdIns-3-kinase type 3, Vps 34