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Anti-YY1 Antibody

Rabbit polyclonal antibody to YY1 from ABclonal (A0856).
Name: Anti-YY1 Antibody
Description: Rabbit polyclonal antibody to YY1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:20 - 1:50.
Reactivity: Human
Immunogen: A synthetic peptide of human YY1.
Protein Length: 414
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).
Sequence Similarities: Belongs to the YY transcription factor family.
Post-Translational Modification: Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.
Cellular Location: Nucleus matrix.

Associated with the nuclear matrix.
UniProt: P25490
Gene ID: 7528
Synonyms: CF1 Antibody
Delta Antibody
Delta transcription factor Antibody
INO80 complex subunit S Antibody
INO80S Antibody
NF E1 Antibody
NF-E1 Antibody
NFE1 Antibody
OTTHUMP00000197459 Antibody
Transcriptional repressor protein YY1 Antibody
TYY1_HUMAN Antibody
UCR motif DNA binding protein Antibody
UCRBP Antibody
Yin and yang 1 Antibody
Yin and Yang 1 protein Antibody
Yin Yang 1 Antibody
Ying Yang 1 Antibody
YY 1 Antibody
YY 1 transcription factor Antibody
YY-1 Antibody
YY1 transcription factor Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of Y79 cell line, using YY1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to YY1
Application: IHC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Fusion protein of human YY1


Description: Rabbit polyclonal antibody to YY1
Application: WB
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide of human YY1


Description: Rabbit Polyclonal Antibody to YY1
Application: ELISA, WB, IP
Host: Rabbit
Isotype: IgG
Immunogen: YY1 transcription factor


Please Note: Anti-YY1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0856
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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