Anti-AHSG Antibody [AHSG/3748] (A277583)

Name: Anti-AHSG Antibody [AHSG/3748]
Brand: Antibodies.com
SKU: A277583
Price: 525.0 USD
Availability: InStock

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$525

Mouse monoclonal [AHSG/3748] antibody to AHSG for IHC-P.

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4-6 Business Days

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Monospecific Antibody

Specifications

Name

Anti-AHSG Antibody [AHSG/3748]

Description

Mouse monoclonal [AHSG/3748] antibody to AHSG.

Specificity

Fetuin (also designated Î±2-z-globulin or Î±2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant fragment corresponding to human AHSG protein. The exact sequence is proprietary.

Host

Mouse

Clonality

Monoclonal

Clone ID

AHSG/3748

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Molecular Weight

59 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-AHSG Antibody [AHSG/3748] - BSA and Azide free (A278171).

Synonyms

59 kDa bone sialic acid-containing protein, A2HS, Aa2-066, AHS, Ahsg alpha-2-HS-glycoprotein, Alpha 2 HS Glycoprotein, Alpha 2 Z globulin, Alpha-2-HS-glycoprotein, Alpha-2-HS-glycoprotein chain B, Alpha-2-Z-globulin, Asialofetuin, Ba alpha 2 glycoprotein, Ba-alpha-2-glycoprotein, BSP, Countertrypin, Fetua, FETUA_HUMAN, Fetuin , mouse, homolog of, Fetuin A, Fetuin-A, Glycoprotein PP63, HSGA, pp63

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (3)

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Figure 1: Immunohistochemistry - Anti-AHSG Antibody [AHSG/3748] (A277583)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue using Anti-AHSG Antibody [AHSG/3748] at 2µg/ml. Inset: PBS instead of the primary antibody. Secondary antibody negative control.

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Figure 2: SDS-PAGE - Anti-AHSG Antibody [AHSG/3748] (A277583)

SDS-PAGE analysis of Anti-AHSG Antibody [AHSG/3748] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 3: Anti-AHSG Antibody [AHSG/3748] (A277583)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-AHSG Antibody [AHSG/3748]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

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