Anti-ALDH1L1 Antibody [ALDH1L1/7958] (A314439)

$765

Mouse monoclonal [ALDH1L1/7958] antibody to ALDH1L1 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-ALDH1L1 Antibody [ALDH1L1/7958]
Description
Mouse monoclonal [ALDH1L1/7958] antibody to ALDH1L1.
Specificity
Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.
Applications
IHC-P
Positive Control
Human kidney or liver.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment of human ALDH1L1 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
ALDH1L1/7958
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
99 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
10 formyltetrahydrofolate dehydrogenase, 10 FTHFDH, 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, AL1L1_HUMAN, Aldehyde dehydrogenase 1 family member L1, Aldehyde dehydrogenase family 1 member L1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, DKFZp781N0997, EC 1.5.1.6, FDH, formyltetrahydrofolate dehydrogenase, FTHFD, OTTHUMP00000155221, OTTHUMP00000214696, OTTHUMP00000214700, OTTHUMP00000222724
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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