Anti-ASK1 (phospho Ser83) Antibody (A283074)

Anti-ASK1 (phospho Ser83) Antibody

Rabbit polyclonal antibody to ASK1 (phospho Ser83).

This antibody recognises apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) and MAPK/ERK kinase kinase 5 (MEKK 5), when phosphorylated at serine 83. ASK1 is a serine/threonine kinase that plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at serine 83 to inhibit ASK1 induced apoptosis.

WB, ELISA

ELISA: 1:5,000 - 1:10,000, WB: 1:1,000

Human

Synthetic peptide corresponding to amino acids 76-87 of human ASK-1 protein, conjugated to Keyhole Limpet Haemocyanin.

ATRGRGSSVGGG

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 155 kDa in SW1353 cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti ASK1 (pSer83) antibody recognizes apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) and MAPK/ERK kinase kinase 5 (MEKK 5), when phosphorylated at serine 83. ASK1 is a serine/threonine kinase that plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at serine 83 to inhibit ASK1 induced apoptosis.

Apoptosis signal regulating kinase 1, Apoptosis signal-regulating kinase 1, ASK 1, ASK-1, M3K5, M3K5_HUMAN, MAP/ERK kinase kinase 5, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, MEK kinase 5, MEKK 5, MEKK5, Mitogen activated protein kinase kinase kinase 5, Mitogen-activated protein kinase kinase kinase 5